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Resistance soon develops, and the tumour startsregrowing even with continued chemotherapy.
Firstly, by using a ?xed %setting of inspiratory time, the inspiratory timewill increase as frequency decreases – so theduration of exposure to the high pressure is lon-ger and higher tidal volumes will be delivered.Secondly, lower resistance and inertance at lowerfrequency results in a higher percentage of theairway-opening pressure amplitude being deliv-ered to the proximal and distal airspaces (seeSect. It was such a strong, fierce lion that theDoctor felt like a mouse. The reader is advised always to check product information(package inserts) for changes and new information regarding dose and contraindications before administering any drug.
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